• Rajesh Sharma Saraswathi Institute of Medical Sciences, Hapur, Uttar Pradesh
  • Richa Sharma Saraswathi Institute of Medical Sciences, Hapur, Uttar Pradesh
  • Jitender Kumar Patel Saraswathi Institute of Medical Sciences Hapur, Uttar Pradesh



Hypothyroidism, HbA1C : Glycosylated hemoglobin, TSH, Type 2 Diabetes mellitus


Background: Diabetes mellitus and thyroid illnesses are the two endocrine conditions that are seen in clinical practice the most frequently. Patients frequently have a tendency to suffer from both diabetes mellitus and thyroid dysfunction at the same time. This article illustrates why it is important to recognize the interdependent relationship that exists between thyroid illness and diabetes.

Method: Present study was conducted among 193 T2DM patients. Patients’ last three month glucose level was measured by HBA1c and thyroid dysfunction evaluated by thyroid profiling. Association and prediction of different variables for developing thyroid dysfunction among diabetic patients was calculated using chi-square, t test and ROC curve.

Result: Out of 193, 47 patients had thyroid dysfunction, majority 22(11.4%) had subclinical hypothyroidism. 13(6.7%) had Hypothyroidism, 6(3.1%) had subclinical Hyperthyroidism, 3(1.5%)  had Hyperthyroidism and 3(1.5%)  patients were euthyroid. The prevalence of established thyroid disease was higher in females 32 (68.1%). Out of 47 patients with thyroid dysfunction, 39(82.9%) patients had HBA1C >6.5%.

Conclusion: Age >50 years and female gender played as risk factor for developing thyroid dysfunction among patients with T2DM. HBA1C >6.5% and TSH more than 3.65mIU/L  was independent risk factor for predicting thyroid dysfunction in T2DM.


Feely J, Isles TE. Screening for thyroid dysfunction in diabetics. Br Med J [Internet]. 1979 Jun 6 [cited 2023 Jun 5];1(6179):1678. Doi: PMid:466176 PMCid:PMC1599205

Roa Dueñas OH, Van Der Burgh AC, Ittermann T, Ligthart S, Ikram MA, Peeters R, et al. Thyroid Function and the Risk of Prediabetes and Type 2 Diabetes. Journal of Clinical Endocrinology and Metabolism. 2022 Jun 1;107(6):1789-98. Doi: PMid:35137143 PMCid:PMC9315162

Mullur R, Liu YY, Brent GA. Thyroid Hormone Regulation of Metabolism. Physiol Rev [Internet]. 2014 [cited 2023 Jun 5];94(2):355. Doi: PMid:24692351 PMCid:PMC4044302

Kalra S, Aggarwal S, Khandelwal D. Thyroid Dysfunction and Type 2 Diabetes Mellitus: Screening Strategies and Implications for Management. Diabetes Therapy [Internet]. 2019 Dec 1 [cited 2023 Jun 5];10(6):2035. Doi: PMid:31583645 PMCid:PMC6848627

Martyn A. Type 2 diabetes in adults. Nurs Stand. 2006;20(30):67.

Jayne Franklyn. UK Guidelines for the Use of Thyroid Function Tests. Consultant. 2006;(July):1-86.

Palma CCSSV, Pavesi M, Nogueira VG, Clemente ELS, Vasconcellos MDFBMP, Pereira LC, et al. Prevalence of thyroid dysfunction in patients with diabetes mellitus. Dia-betol Metab Syndr [Internet]. 2013 [cited 2023 Jun 5];5(1):58. Doi: PMid:24499529 PMCid:PMC3852595

Ozair M, Noor S, Raghav A, Siddiqi SS, Chugtai AM, Ah-mad J. Prevalence of thyroid disorders in North Indian Type 2 diabetic subjects: A cross sectional study. Diabetes Metab Syndr [Internet]. 2018 May 1 [cited 2023 Jun 5];12(3):301-4. Doi: PMid:29279270

Jali M V., Kambar S, Jali SM, Pawar N, Nalawade P. Preva-lence of thyroid dysfunction among type 2 diabetes melli-tus patients. Diabetes Metab Syndr [Internet]. 2017 Nov 1 [cited 2023 Jun 5];11 Suppl 1:S105-8. Doi: PMid:28057505

Khassawneh AH, Al-Mistarehi AH, Alaabdin AMZ, Khasawneh L, Alquran TM, Kheirallah KA, et al. Prevalence and Predictors of Thyroid Dysfunction Among Type 2 Diabetic Patients: A Case-Control Study. Int J Gen Med [Internet]. 2020 Oct 12 [cited 2023 Jun 6];13:803-16. Doi: PMid:33116772 PMCid:PMC7568427

Defining Adult Overweight & Obesity | Overweight & Obesity | CDC [Internet]. [cited 2023 Jun 8]. Available from:

What is HbA1c? | Blood Test | Target Levels | Diabetes UK [Internet]. [cited 2023 Jun 8]. Available from:

Silva R do C. [Importance of thyroid function evaluation in patients with diabetes mellitus]. Arq Bras Endocrinol Metabol [Internet]. 2005 [cited 2023 Jun 7];49(2):180-2. Doi: PMid:16184245

Umpierrez GE, Latif KA, Murphy MB, Lambeth HC, Stentz F, Bush A, et al. Thyroid dysfunction in patients with type 1 diabetes: a longitudinal study. Diabetes Care [Internet]. 2003 Apr 1 [cited 2023 Jun 7];26(4):1181-5. Doi: PMid:12663594

Aversa T, Valenzise M, Corrias A, Salerno M, De Luca F, Mussa A, et al. Underlying Hashimoto's thyroiditis negatively affects the evolution of subclinical hypothyroidism in children irrespective of other concomitant risk factors. Thyroid [Internet]. 2015 Feb 1 [cited 2023 Jun 7];25(2):183-7. Doi: PMid:25364860

Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT. Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Associ-ation, and the Endocrine Society. J Clin Endocrinol Metab [Internet]. 2005 Jan [cited 2023 Jun 7];90(1):581-5. Doi: PMid:15687817

Rong F, Dai H, Wu Y, Li J, Liu G, Chen H, et al. Association between thyroid dysfunction and type 2 diabetes: a meta-analysis of prospective observational studies. BMC Med [Internet]. 2021 Dec 1 [cited 2023 Jun 7];19(1). Doi: PMid:34670571 PMCid:PMC8529738

Gesing A. The thyroid gland and the process of aging. Thyroid Res [Internet]. 2015 [cited 2023 Jun 7];8(Suppl 1):A8. Doi: PMCid:PMC4480281

Ogbonna SU, Ezeani IU. Risk Factors of Thyroid Dysfunction in Patients with Type 2 Diabetes Mellitus. Front Endocrinol (Lausanne) [Internet]. 2019 [cited 2023 Jun 7];10(JULY):440. Doi: PMid:31333585 PMCid:PMC6621929

Han M, Wu H, Yang W, Chen J. Analysis of risk factors for the development of type 2 diabetes mellitus complicated with Hashimoto's thyroiditis. BMC Endocr Disord [Inter-net]. 2022 Dec 1 [cited 2023 Jun 7];22(1):1-7. Doi: PMid:35804367 PMCid:PMC9264533




How to Cite

Sharma, R., Sharma, R., & Patel, J. K. (2023). HOW THYROID PROFILE IS AFFECTED BY DIABETIC MELLITUS: A CROSS SECTIONAL STUDY. National Journal of Medical Research, 13(02), 39–43.



Original Research Articles

Similar Articles

You may also start an advanced similarity search for this article.