Bridging Clinical Practice and Research: The Importance of Translational Medicine

Coller BS, Califf RM. Translational research: hitching basic and clinical research to a collaborative, translational enterprise. J Clin Invest. 2009;119(4): 999-1005.

Sung NS, Crowley WF Jr, Genel M, et al. Central challenges facing the national clinical research enterprise. JAMA. 2003; 289(10):1278-1287. Doi: https://doi.org/10.1001/jama.289.10.1278 DOI: https://doi.org/10.1001/jama.289.10.1278

Khoury MJ, Gwinn M, Yoon PW, et al. The continuum of translation research in genomic medicine: how can we accel-erate the appropriate integration of human genome discover-ies into health care and disease prevention? Genet Med. 2007;9(10):665-674. Doi: https://doi.org/10.1097/GIM.0b013e31815699d0 DOI: https://doi.org/10.1097/GIM.0b013e31815699d0

Shields RL, Namenuk AK, Hong K, et al. High resolution map-ping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 var-iants with improved binding to the Fc gamma R. J Biol Chem. 2001;276(9):6591-6604. Doi: https://doi.org/10.1074/jbc.M009483200 DOI: https://doi.org/10.1074/jbc.M009483200

Tannock IF, Hickman JA. Limits to personalized cancer medi-cine. N Engl J Med. 2016;375(13):1289-1294. Doi: https://doi.org/10.1056/NEJMsb1607705 DOI: https://doi.org/10.1056/NEJMsb1607705

Jackson NA, Kester KE, Casimiro D, et al. The promise of mRNA vaccines: a biotech and industrial perspective. NPJ Vaccines. 2020; 5:11. Doi: https://doi.org/10.1038/s41541-020-0159-8 DOI: https://doi.org/10.1038/s41541-020-0159-8

Mokhtari RB, Homayouni TS, Baluch N, et al. Combination therapy in combating cancer. Oncotarget. 2017;8(23):38022-38043. Doi: https://doi.org/10.18632/oncotarget.16723 DOI: https://doi.org/10.18632/oncotarget.16723

Kay MA. State-of-the-art gene-based therapies: the road ahead. Nat Rev Genet. 2011;12(5):316-328. Doi: https://doi.org/10.1038/nrg2971 DOI: https://doi.org/10.1038/nrg2971

Garber K. Failure of animal models for cancer clinical trials: how strong is the correlation? Nature. 2009;460(7252): 157. Doi: https://doi.org/10.1038/460157a DOI: https://doi.org/10.1038/460157a

Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372(9):793-795. Doi: https://doi.org/10.1056/NEJMp1500523 DOI: https://doi.org/10.1056/NEJMp1500523

Butcher EC, Berg EL, Kunkel EJ. Systems biology in drug discovery. Nat Biotechnol. 2004; 22(10): 1253-1259. Doi: https://doi.org/10.1038/nbt1017 DOI: https://doi.org/10.1038/nbt1017

Sugarman J. Ethics in translational research: making it work. JAMA. 2010;304(7):773-774. Doi: https://doi.org/10.1001/jama.2010.1181 DOI: https://doi.org/10.1001/jama.2010.1181

Woodcock J, LaVange LM. Master protocols to study multi-ple therapies, multiple diseases, or both. N Engl J Med. 2017; 377(1):62-70. Doi: https://doi.org/10.1056/NEJMra1510062 DOI: https://doi.org/10.1056/NEJMra1510062

Corey DR. RNA learns from CRISPR: A breakthrough in gene editing and regulation. Cell Chem Biol. 2017;24(8):944-948. Doi: https://doi.org/10.1016/j.chembiol.2017.07.005 DOI: https://doi.org/10.1016/j.chembiol.2017.07.005

Beam AL, Kohane IS. Big data and machine learning in health care. JAMA. 2018;319(13):1317-1318. Doi: https://doi.org/10.1001/jama.2017.18391 DOI: https://doi.org/10.1001/jama.2017.18391

Doudna JA, Charpentier E. The new frontier of genome engi-neering with CRISPR-Cas9. Science. 2014;346(6213):1258096. Doi: https://doi.org/10.1126/science.1258096 DOI: https://doi.org/10.1126/science.1258096

Ribas A, Wolchok JD. Cancer immunotherapy using check-point blockade. Science. 2018;359(6382):1350-1355. Doi: https://doi.org/10.1126/science.aar4060 DOI: https://doi.org/10.1126/science.aar4060