Unravelling the Role of Plasma Fibrinogen in Acute Stroke


  • Shouvik Datta Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, India
  • Mahesh Kumar Mehrotra Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, India
  • Jasleen Kaur Hura Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, India




Case-control study, Fibrinogen, Haemorrhagic stroke, Ischemic stroke


Background: A stroke is described as a sudden neurological deficit with a focused vascular origin. Atrial fibrillation, carotid stenosis, myocardial infarction, hypertension, diabetes, hyperlipidaemia, obesity, smoking and atrial myxomas are all risk factors for stroke. Stroke mortality in urban India accounts for 1% of all hospital admissions, 4% of all medical cases, and around 20% of all central nervous system illnesses. Diabetes, hypertension, smoking, and hyperlipidaemia are risk factors for stroke and have been linked to alterations in haematology and coagulation, including elevated fibrinogen levels.

Methodology: The present case-control study was conducted among 50 cases of acute stroke and 50 controls without stroke history. Plasma fibrinogen of 50 consecutive patients with acute stroke presenting to the OPD/Casualty or getting admitted to Shri Ram Murti Smark Institute of Medical Sciences was compared with 50 controls who is not suffering from stroke. An unpaired t-test was applied to compare the mean fibrinogen level of the two groups. For statistical significance p value less than 0.05 was taken with 95% confidence interval.

Result: fibrinogen level among the control group (267.0±98) was low compared to patients with overall stroke (428.8±97.8), either ischemic (470±80.5) or haemorrhagic stroke (387.6±97.6).

Conclusion: Patients with Ischemic Stroke having a mean Fibrinogen level of (508.8 mg/dL ± 74.6) and haemorrhagic stroke with 487.5±66 mean fibrinogen level had the worst outcome. There was a significant difference in mean fibrinogen levels among survival and non-survival groups of patients in ischemic and haemorrhagic stroke.


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How to Cite

Datta, S., Mehrotra, M. K., & Hura, J. K. (2024). Unravelling the Role of Plasma Fibrinogen in Acute Stroke. National Journal of Medical Research, 14(03), 80–84. https://doi.org/10.55489/njmr.14032024999



Original Research Articles