A Comparative Study of Serum Lipid Profile and Common Bile Duct Dimensions in Pre and Post Cholecystectomy Patients

Authors

  • Suryateja Reddy Dr D Y Patil Medical College Hospital and Research Centre, Pimpri, Pune, India
  • Iqbal Ali Dr D Y Patil Medical College Hospital and Research Centre, Pimpri, Pune, India
  • Virendra S Athavale Dr D Y Patil Medical College Hospital and Research Centre, Pimpri, Pune, India
  • Prabhat B Nichkaode Dr D Y Patil Medical College Hospital and Research Centre, Pimpri, Pune, India
  • Trupti Tonape Dr D Y Patil Medical College Hospital and Research Centre, Pimpri, Pune, India
  • Anuradha Dnyanmote Dr D Y Patil Medical College Hospital and Research Centre, Pimpri, Pune, India

DOI:

https://doi.org/10.55489/njmr.14022024997

Keywords:

Cholecystectomy, Common Bile Duct, Cholesterol, Lipid Profile, CBD diameter

Abstract

Introduction: Post cholecystectomy the common bile duct dilates in an effort to restore the storage function of gall bladder and helps in metabolism of lipids. There are many studies determining the association of abnormal lipid parameters with gall stones but there are not many studies comparing the diameter of CBD pre and post cholecystectomy and its clinical implication.

Hence, under the light of above-mentioned data, we planned the present study to assess the effect of cholecystectomy on common bile duct diameter and lipid profile.

Methodology: Patients with gall bladder stone eligible for cholecystectomy were included in the study. In this study pre and post operative cholecystectomy values of lipid profile and CBD diameter were compared. Patients were followed up till one year post operative to assess changes.

Results: Out of total 55 cases included in the study 38.2% were male and 78.2% has mixed type of stone. Post operatively Serum cholesterol, triglyceride, HDL and LDL value improved significantly at the end of one year follow up (p<0.01). Pre operative mean CBD diameter was 4.38 mm which was increased to 5.6 mm at the end of one year post operatively (p<0.01)

Conclusion: Cholecystectomy leads to significant impact on in lipid profile. Significant compensatory dilatation of common bile duct diameter occurs post cholecystectomy. This indicates a very positive impact of cholecystectomy on lipid profile.

References

Stinton LM, Shaffer E: Epidemiology of gallbladder disease: cholelithiasis and cancer, Gut Liver 6:172-187, 2012. Doi: https://doi.org/10.5009/gnl.2012.6.2.172 PMid:22570746 PMCid:PMC3343155

Atamanalp RS. Is there a relationship between the serum cho-lesterol level and the biochemical structure of gallstone in pa-tients with cholelithiasis? IB Extended Essay. 2012;1-20.

Einarsson K, Hellström K, Kallner M. Gallbladder disease in hyper lipoproteinaemia. Lancet. 1975;1(7905):484-87. Doi: https://doi.org/10.1016/S0140-6736(75)92831-7 PMid:46958

Dowling RH. Review: pathogenesis of gallstones. Aliment PharmacolTher. 2000;14 (Suppl 2):39-47. Doi: https://doi.org/10.1046/j.1365-2036.2000.014s2039.x PMid:10903002

Nahrwold DL. Historical aspects the biliary system Sabistan Textbook of Surgery,14th ed.1991:1042.

Edmunds R, Katz S, Garciano V and Finby N. The common duct after cholecystectomy. Arch surg. 1971;103:79-81. Doi: https://doi.org/10.1001/archsurg.1971.01350070105025 PMid:5088437

Ahi KS, Singh RP, Kaur H, Moudgil A. Serum Lipid Profile in Pre and Post Cholecystectomy Patients. Intl J Anat, Rad Surg. 2017;6(2): SO01-SO06 DOI: 10.7860/IJARS/2017/27123:2267.

Jain A, Singh MM, Choudhary P. Effect Of Cholecystectomy On Serum Lipid Profile. Global J Res Analysis. 2018; 7(4):428-429.

Yogendra Kumar, Neelkamal Gola, Vinod Kapoor. Effect of Cholecystectomy on Serum Lipid Profile in Gallstone Patients: A Comparative Study. Int J Med Res Prof. 2018 Mar; 4(2):112-14. DOI:10.21276/ijmrp.2018.4.2.024

Jindal N, Singh G, Ali I, Sali G, Reddy R. Effect of cholelithiasis and cholecystectomy on serum lipids and blood glucose pa-rameters. Arch Int Surg 2013;3:97-101. Doi: https://doi.org/10.4103/2278-9596.122926

Atamanalp SS, Keles MS et al. The effects of serum cholester-ol, LDL, and HDL levels on gallstone cholesterol concentra-tion. Pakistan Journal of Medical Sciences. 2013;29(1):187-190. Doi: https://doi.org/10.12669/pjms.291.2798 PMid:24353537 PMCid:PMC3809189

Khokhlacheva NA et al. Wether cholecystectomy affects bile lithogenicity in cholelithiasis. Eksp Klin Gastroenterol. 2012;(4):11-5.

Batajoo H, Hazra NK. Analysis of serum lipid profile in choleli-thiasis patients. J Nepal Health Res Counc. 2013 Jan;11(23):53-5

Puestow CB, Morrison RB. The relationship of cholecystitis and cholecystectomy to dilatation of the choledochus. Ann Surg. 1935;101:599-602. Doi: https://doi.org/10.1097/00000658-193501000-00065 PMid:17856489 PMCid:PMC1391118

Graham MF, Cooperberg PL, Cohen MM, Burhenne HJ. The size of the normal common hepatic duct following cholecys-tectomy: an ultrasonographic study. Radiology. 1980;135:137-139. Doi: https://doi.org/10.1148/radiology.135.1.7360951 PMid:7360951

Mueller PR, Ferrucci JT, Jr, Simeone JF, Wittenberg J, van-Sonnenberg E, Polansky A, et al. Post cholecystectomy bile duct dilatation: myth or reality? AJR Am J Roentgenol. 1981;136:355-358. Doi: https://doi.org/10.2214/ajr.136.2.355 PMid:6781258

Hunt DR, Scott AJ. Changes in bile duct diameter after chole-cystectomy: a 5-year prospective study. Gastroenterology. 1989; 97: 1485-1488. Doi: https://doi.org/10.1016/0016-5085(89)90393-4 PMid:2684721

Majeed AW, Ross B, Johnson AG. The preoperatively normal bile duct does not dilate after cholecystectomy: results of a five year study. Gut. 1999; 45: 741-743. Doi: https://doi.org/10.1136/gut.45.5.741 PMid:10517913 PMCid:PMC1727736

Csendes GP, Csendes JA, Burgos LA, Burdiles PP. Bile duct diameter before and 12 years after cholecystectomy. Rev Med Chil. 2007; 135: 735-742. Doi: https://doi.org/10.4067/S0034-98872007000600007

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Published

2024-04-01

How to Cite

Reddy, S., Ali, I., Athavale, V. S., Nichkaode, P. B., Tonape, T., & Dnyanmote, A. (2024). A Comparative Study of Serum Lipid Profile and Common Bile Duct Dimensions in Pre and Post Cholecystectomy Patients. National Journal of Medical Research, 14(02), 66–71. https://doi.org/10.55489/njmr.14022024997

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Original Research Articles