Diagnostic Ability of Nerve Conduction Study, Ultrasonography and Magnetic Resonance Imaging in Diagnosis of Carpel Tunnel Syndrome
DOI:
https://doi.org/10.55489/njmr.13042023981Keywords:
Carpel Tunnel Syndrome, CTS, median nerve cross sectional area, Nerve conduction study, velocity, Amplitude, sensory nerve action potentialAbstract
Introduction: Current diagnostic criteria for Carpel Tunnel Syndrome (CTS) include a patient's medical history, physical exam results, and electrophysiological findings. The purpose of the study is to evaluate the diagnostic ability of nerve conduction study, ultrasonography and magnetic resonance imaging for the diagnosis of carpal tunnel syndrome with the use of clinical findings as the gold standard.
Methodology: The study was conducted among 30 patients clinically diagnosed having CTS based on the criteria given by American Academy of Neurology and American Academy of Physical Medicine and Rehabilitation. All patients included in the study were underwent USG of affected wrist joint, CT scan as well MRI of the same.
Results: Out of total 30 participants, 14 (46.7%) were found moderate severity followed by 11 (36.7%) were found mild severity. Only 5 (16.7%) were found severe carpel tunnel syndrome. Amongst all three investigation methods, nerve conduction study having the lowest sensitivity (83.33%). The sensitivity of the ultrasonography and MRI was 90% each.
Conclusion: It is clear from this study that the sensitivity of the parameters utilized in NCS (maximum observed 83.33%) is lower than that of the median nerve cross-sectional area detected on USG (90%) and MRI (90%). The most sensitive, practical, and cost-effective metric of all those seen in the research turned out to be the median nerve cross sectional area evaluated at the wrist crease by USG.
References
Thatte MR, Mansukhani KA. Compressive neuropathy in the upper limb. Indian J Plast Surg. 2011;44(2):283-97. Doi: https://doi.org/10.4103/0970-0358.85350 PMid:22022039 PMCid:PMC3193641
Kao SY. Carpel tunnel syndrome as an occupational disease. J Am Board Fam Pract. 2003;16(6):533-42. Doi: https://doi.org/10.3122/jabfm.16.6.533 PMid:14963080
Atcheson SG, Ward JR, Lowe W. Concurrent medical disease in work related carpal tunnel syndrome. Arch Intern Med. 1998;158(14):1506-12. Doi: https://doi.org/10.1001/archinte.158.14.1506 PMid:9679791
Fu T, Cao M, Liu F, Zhu J, Ye D, Feng X, et al. Carpal tunnel syndrome assessment with ultrasonography: Value of inlet-to-outlet median nerve area ratio in patients versus healthyvolun-teers. 2015;10(1):e0116777; Doi: https://doi.org/10.1371/journal.pone.0116777 PMid:25617835 PMCid:PMC4305299
Cartwright MS, Passmore LV, Yoon JS, Brown ME, Caress JB, et al. Crosssectional area reference values for nerve ultrasonography. Muscle Nerve. 2008;37:566-71. Doi: https://doi.org/10.1002/mus.21009 PMid:18351581
Jablecki CK, Andary MT, Flocter MK, Miller RG, Quartly CA, Vennix MJ, et al. Practice parameter: Electrodiagnostic studies in carpal tunnel syndrome. Report of the American Association of Electrodiagnostic Medicine, American Academy of Neurolo-gy, and the American Academy of Physical Medicine and Rehabilitation. Neurology. 2002;58(11):589-92. Doi: https://doi.org/10.1212/WNL.58.11.1589 PMid:12058083
Buchberger W, Judmaier W, Birbamer G, Lener M, Schmidauer C. Carpal tunnel syndrome: Diagnosis with highresolution sonography. AJR Am J Roentgenol. 1992;159(4):793-98. Doi: https://doi.org/10.2214/ajr.159.4.1529845 PMid:1529845
Roghani RS, Holisaz MT, Norouzi AS, Delbari A, Gohari F, Lokk J, et al. Sensitivity of high-resolution ultrasonography in clinically diagnosed carpal tunnel syndrome patients with hand pain and normal nerve conduction studies. J Pain Res. 2018;11:1319-25. Doi: https://doi.org/10.2147/JPR.S164004 PMid:30022850 PMCid:PMC6044364
Fowler JR, Cipolli W, Hanson T. A comparison of three diagnostic tests for carpal tunnel syndrome using latent class analysis. J Bone Joint Surg Am. 2015;97(23):1958-61. Doi: https://doi.org/10.2106/JBJS.O.00476 PMid:26631997
Altinok T, Baysal O, Karakas HM, Sigirci A, Alkan A, Kayhan A, et al. Ultrasonographic assessment of mild and moderate idio-pathic carpal tunnel syndrome. Clin Radiol. 2004;59(10):916-25. Doi: https://doi.org/10.1016/j.crad.2004.03.019 PMid:15451352
Duncan I, Sullivan P, Lomas F. Sonography in the diagnosis of carpal tunnel syndrome. AJR Am J Roentgenol. 1999;173(3):681-84. Doi: https://doi.org/10.2214/ajr.173.3.10470903 PMid:10470903
Lee D, van Holsbeeck MT, Janevski PK, Ganos DL, Ditmars DM, Darian VB. Diagnosis of carpal tunnel syndrome: ultra-sound versus electromyography. Radiol Clin North Am 1999; 37:859 - 872. Doi: https://doi.org/10.1016/S0033-8389(05)70132-9 PMid:10442084
Wong SM, Griffth JF, Hui AC, Lo SK, Fu M, et al. Carpal tunnel syndrome: Diagnostic usefulness of sonography. Radiology. 2004;232:93-99. Doi: https://doi.org/10.1148/radiol.2321030071 PMid:15155897
Baiee RH, Almukhtar N, Al-Rubaie SJ, Hammoodi ZH. Neuro-physiological findings in patients with carpal tunnel syndrome by nerve conduction study in comparing with ultrasound study. Journal of Natural Sciences Research. 2015;5(16):111-28.
Kwon HK, Kang HJ, Byun CW, Yoon JS, Kang CH, Pyun SB. Correlation between ultrasonography findings and electrodiagnostic severity in carpal tunnel syndrome: 3D ultrasonography. J Clin Neurol. 2014;10(4):348-53. Doi: https://doi.org/10.3988/jcn.2014.10.4.348 PMid:25324885 PMCid:PMC4198717
Kasundra GM, Sood I, Bhargava AN, Bhushan B, Rana K, Jangid H, et al. Carpal tunnel syndrome: Analyzing efficacy and utility of clinical tests and various diagnostic modalities. J Neurosci Rural Pract 2015;6:504-10. Doi: https://doi.org/10.4103/0976-3147.169867 PMid:26752893 PMCid:PMC4692006
Kanikannan MA, Boddu DB, Umamahesh, Sarva S, Durga P, Borgohain R. Comparison of high-resolution sonography and electrophysiology in the diagnosis of carpal tunnel syndrome. Ann Indian Acad Neurol. 2015;18(2):219-25. Doi: https://doi.org/10.4103/0972-2327.150590 PMid:26019423 PMCid:PMC4445201
El Miedany YM, Aty SA, Ashour S. Ultrasonography versus nerve conduction study in patients with carpal tunnel syndrome: substantive or complementary tests? Rheumatology (Oxford) 2004;43:887-895. Doi: https://doi.org/10.1093/rheumatology/keh190 PMid:15100417
Wong SM, Griffith JF, Hui AC, Tang A, Wong KS. Discriminatory sonographic criteria for the diagnosis of carpal tunnel syndrome. Arthritis Rheum 2002; 46:1914-1921. Doi: https://doi.org/10.1002/art.10385 PMid:12124876
Aroori S, Spence RA. Carpal tunnel syndrome. Ulster Med J. 2008 Jan;77(1):6-17. PMID: 18269111; PMCID: PMC2397020.
Salerno DF, Werner RA, Albers JW, Becker MP, Armstrong TJ, Franzblau A. Reliability of nerve conduction studies among active workers. Muscle Nerve. 1999;22(10):1372-79. Doi: https://doi.org/10.1002/(SICI)1097-4598(199910)22:10<1372::AID-MUS6>3.0.CO;2-S
Ogura T, Akiyo N, Kubo T, Kira Y, Aramaki S, Nakanishi F. The relationship between nerve conduction study and clinical grading of carpal tunnel syndrome. Journal of Orthopedic Surgery. 2003: 11(2): 190-93. Doi: https://doi.org/10.1177/230949900301100215 PMid:14676346
Werner RA, Andary M. Electrodiagnostic evaluation of carpal tunnel syndrome. Muscle Nerve. 2011;44(4):597-607. Doi: https://doi.org/10.1002/mus.22208 PMid:21922474
American Academy of Orthopaedic Surgeons. Clinical Practice Guideline on the Treatment of Carpal Tunnel Syndrome. Muscle Nerve. 2011;44:597-607. Doi: https://doi.org/10.1002/mus.22208 PMid:21922474
American Association of Electrodiagnostic Medicine, American Academy of Neurology and American Academy of Physical Medicine and Rehabilitation Practice parameter for electrodiagnostic studies in carpal tunnel syndrome: summary statement. Muscle Nerve. 2002;25:918-22. Doi: https://doi.org/10.1002/mus.10185 PMid:12115985
Srikanteswara PK, Cheluvaiah JD, Agadi JB, Nagaraj K. The Relationship between Nerve Conduction Study and Clinical Grad-ing of Carpal Tunnel Syndrome. J Clin Diagn Res. 2016 Jul;10(7):OC13-8. doi: 10.7860/JCDR/2016/20607.8097. Epub 2016 Jul 1. PMID: 27630881; PMCID: PMC5020228.
Lee SH, Lee SH, Chan VW, Lee JO, Kim HI. Echotexture and correlated histologic analysis of peripheral nerves important in regional anesthesia. Reg. Anesth. Pain Med. 36(4), 382-386 (2011). Doi: https://doi.org/10.1097/AAP.0b013e318217a7a0 PMid:21555966
Bayrak IK, Bayrak AO, Tilki HE, Nural MS, Sunter T. Ultrasonography in carpal tunnel syndrome: Comparison with electrophysiological stage and motor unit number estimate. Mus-cle Nerve 2007;35:344-8. Doi: https://doi.org/10.1002/mus.20698 PMid:17143879
Karadag YS, Karadag Ö, Cicekli E et al. Severity of carpal tunnel syndrome assessed with high frequency ultrasonography. Rheumatol. Int. 30, 761-765 (2010). Doi: https://doi.org/10.1007/s00296-009-1061-x PMid:19593567
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