• Shubhrangshu Banerjee Mymensingh Medical College Hospital, Bangladesh
  • Manabendra Bhattacharjee Mymensingh Medical College Hospital, Bangladesh
  • Uttam Kumar Sarker Mymensingh Medical College Hospital, Bangladesh
  • Shitangshu Banerjee Rajshahi Medical College Hospital, Bangladesh



Non-alcoholic fatty liver disease (NAFLD), Obesity, Public health


Background: Non-alcoholic fatty liver disease (NAFLD) commonly results in cirrhosis and liver related death. Obesity is associated with an increased risk of non-alcoholic fatty liver disease. NAFLD has become an important public health problem throughout the globe. The aim of this study was to see frequency of NAFLD among obese patients admitted at the Department of Medicine of Mymensingh Medical College Hospital.

Methods: A total of 100 obese patients having BMI ≥25 kg/M2 were included in this cross-sectional study. Patients’ characteristics, laboratory and face-to-face interview data were analyzed.

Results: Mean age of the patients was 52.61 (SD ± 7.02) years. It was found that more patients were from 51-60 years age group (39%); followed by 41-50 years age group (28%). NAFLD was found in 79% of obese adult patients. Laboratory parameters including TG, HDL, FBG and high blood pressure were compared between NAFLD and normal obese groups. There were no significant differences between the two groups except for FBG. NAFLD patients suffered more from high blood sugar than normal obese patients. Higher intake of meat, increased smoking, lower intake of fish, higher intake of soft drinks & FBG value over 6.1 mmol/L were identified as risk factors for the development of NAFLD.

Conclusion: NAFLD is emerging as one of the most common liver disorders claiming urgent attention of the public, clinicians and researchers. Further in-depth, large scale prospective studies are necessary to dig out more information in this topic.


Mavrogiannaki AN, Migdalis IN. Non-alcoholic Fatty liver disease, diabetes mellitus and cardiovascular disease newer data. Int J Endocrine. 2013:450-639. Doi: PMid:23653642 PMCid:PMC3638654

Anstee QM, Jones DEJ. Liver and biliary tract disease. In: Walker BR, Colledge NR, Ralston SH, Penman ID, editors. Davidson's Principles and Practice of Medicine. 22nd ed. Churchill Livingstone Elsevier; 2014.

Kotronen A, Yki-Jarvinen H, Mannisto S, Saarikoski L, Kor-pi-Hyovalti E, Oksa H, et al. Non-alcoholic and alcoholic fatty liver disease - two diseases of affluence associated with the metabolic syndrome and type 2 diabetes: the FIN-D2D survey. BMC Public Health 2010; 10: 237. Doi: PMid:20459722 PMCid:PMC2873937

Clark JM, Diehl AM. Non-alcoholic Fatty liver disease an Unrecognized cause of Cryptogenic cirrhosis. JAMA. 2003; 289(22):3000-4. Doi: PMid:12799409

Loria P, Carulli L, Bertolotti M, Lonar do A. Endocrine and liver interaction; the role of endocrine pathways in NASH. nat rev Gastroenterol Hepatol. 2009; 6:236-247. Doi: PMid:19347015

Vernon G. Baranova A, Younossi ZM, Systematic Review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic Steatohepatitis in adults. Aliment Pharmacol Ther. 2011; 34: 274-285. Doi: PMid:21623852

Kistler KD, Brunt EM, Clark JM, Diehl AM, Sallis JF, Schwimmer JB. Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease. Am J Gastroenterol 2011; 106: 460-468. Doi: PMid:21206486 PMCid:PMC3070294

Schuppan D, Gorrell MD, Klein T, Mark M, Afdhal NH. The challenge of developing novel pharmacological therapies for non-alcoholic steatohepatitis. Liver Int 2010; 30: 795-808. Doi: PMid:20624207

Hou XH, Zhu YX, Lu HJ, Chen HF, Li Q, Jiang S, et al. Non-alcoholic fatty liver disease's prevalence and impact on alanine aminotransferase associated with metabolic syndrome in the Chinese. J Gastroenterol Hepatol 2011; 26: 722-30. Doi: PMid:21418302

Obesity: preventing and managing the global epidemic. Re-port of a WHO consultation. World health organ tech, Rep ser 2000; 894 I-XII, 1-253.

Finucane MM, Stevens GA, Cowas MJ, Riley LM, Ezzati M. Nationas, regional, and global trends in body -mass index since 1980: Systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 91 million participants. Lancets. 2011; 377: 557-567. Doi: PMid:21295846

Williams CD, Stengel J, Asike MI, Harrison SA. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a Ultrasound and liver biopsy; prospective study. Gastroenterology. 2011; 140:124-131. Doi: PMid:20858492

Bellentani S, Saccoccio G, Masutti F, Prevalence of and risk factors for hepatic Steatosis in Northern Italy. Ann Intern Med. 2000; 132:112-117. Doi: PMid:10644271

Azad MAK, Quayum SL, Mohammad H. Non- alcoholic Fatty liver disease. A disease of New Era: J Medicine. 2007; (8): 17-27. Doi:

Matteon CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, Mccullough AJ. Non-alcoholic Fatty liver disease: a spectrum of clinical pathological severity. Gastroenterology. 1999; 116(6):1413-1419. Doi: PMid:10348825

Bedside ultrasound in the diagnosis of nonalcoholic fatty liver disease. World j Gastroenterol. 2014;2(22):6821-6825. Doi: PMid:24944472 PMCid:PMC4051921

Douglus G, The general examination, IN Fione Nicol, macleods clinical examination.12 edition. churchill livingstone. 2009.

National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Circulation 2002; 106(25):3143-421. Doi: PMid:12485966

American Heritage dictionary of English language. [Inter-net]. 4th ed. Boston, Massachusetts: Houghton Mifflin Harcourt; 2015. laborious; p.229 -30. [cited 2016 Oct 27]. Available from: http://

Agrawal R, Mishra S, Dixit VK, Rai S. Association of Non-Alcoholic Fatty Liver Disorder with Obesity. Indian J Prev Soc Med. 2009;40 (3):126-129.

Adams LA, Sanderson S, Lindor KD, Angilo P. The histological course of non alcoholic fatty liver disease. A longitudinal study of 103 patients with sequential liver biopsies. J hepatal. 2005;42:132 -138. Doi: PMid:15629518

Acharya, Madam. Clinical, biochemical and histological pro-file of patients with nonalcoholic steatohepatitis (NASH) from Northern India. Proceeding of first consensus meet on NAFLD. 2005. 86.

Timothy C, Jennifer KL. Association of Cardio respiratory fitness, Body mass index and waist circumference to non alcoholic Fatty liver disease. Gastroenteralogy. 2006; 130: 2023-2030. Doi: PMid:16762625

E Expert Panel on Detection. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP). JAMA. 2001;285 (19):2486-2497. Doi: PMid:11368702




How to Cite

Banerjee, S., Bhattacharjee, M., Sarker, U. K., & Banerjee, S. (2023). NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) AMONG OBESE PATIENTS IN A TERTIARY CARE HOSPITAL. National Journal of Medical Research, 13(03), 74–79.



Original Research Articles