Association of serum level of vitamin D3 and pulmonary function in bronchial asthma Patients in tertiary care hospital of South Gujarat

Priyank Parmar; Neha Dutt; Bijoy  Desai; Vandana  Dhangar

doi:10.55489/njmr.12042022909

Authors

Priyank Parmar Surat Municipal Institute of Medical Education and Research, Surat, India
Neha Dutt Surat Municipal Institute of Medical Education and Research, Surat, India
Bijoy Desai Surat Municipal Institute of Medical Education and Research, Surat, India
Vandana Dhangar Surat Municipal Institute of Medical Education and Research, Surat, India

DOI:

https://doi.org/10.55489/njmr.12042022909

Keywords:

Vitamin D3, Bronchial asthma, Pulmonary function tests, Tertiary Care Center

Abstract

Introduction: Asthma is a chronic lung disease characterised by reversible airway obstruction, cellular infiltration, and airway inflammation. The reaction is characterised by the interaction of genetic and environmental variables, as well as the activation of cells in the innate and adaptive immune systems.

Method: The study was conducted in the Department of General medicine, in Tertiary Care Center, to study association of serum level of Vitamin D3 and pulmonary function in bronchial asthma patients. As per inclusion and exclusion criteria ,137 patients of bronchial asthma were included in the study.

Result: In cases having serum vitamin D3 level <20 ng/ml mean value of FVC, FEV1, FEV1/FVC ratio, was 108.10±14.89, 68.56±13.40, and 62.35±5.17. In cases having serum vitamin D3 20-29 ng/ml, mean value of FVC, FEV1, and FEV1/FVC ratio was 109.72±12.22, 72.34±13.48, and 64.39±6.97. In cases having serum vitamin D3 >30 ng/ml mean value of FVC, FEV1, and FEV1/FVC ratio, was 115.0±4.27, 81.0±7.09, and 70.52±5.00.

Conclusion: Vitamin D3 deficiency was highly prevalent in asthmatic patients, there was a strong correlation between asthma severity and vitamin D3 concentrations and there was a direct and a positive significant correlation between vitamin D3 levels and pulmonary function test in asthmatic patients.

References

Hall SC, Fischer KD, Agrawal DK. The impact of vitamin D on asthmatic human airway smooth muscle. Expert Rev Respir Med [Internet]. 2016 Feb 1 [cited 2022 Oct 8];10(2):127-35. Doi: https://doi.org/10.1586/17476348.2016.1128326 PMid:26634624 PMCid:PMC4955853

Global Asthma Network the Global Asthma Report 2018 [Internet]. 2018. Available from: www.globalasthmanetwork.org

Fergeson JE, Patel SS, Lockey RF. Acute asthma, prognosis, and treatment. J Allergy Clin Immunol [Internet]. 2016 Aug 20 [cited 2022 Oct 8];139(2):438-47. Doi: https://doi.org/10.1016/j.jaci.2016.06.054 PMid:27554811

Barragan M, Good M, Kolls JK. Regulation of Dendritic Cell Function by Vitamin D. Nutrients [Internet]. 2015 [cited 2022 Oct 8];7(9):8127. Doi: https://doi.org/10.3390/nu7095383 PMid:26402698 PMCid:PMC4586578

Mirzakhani H, Al-Garawi A, Weiss ST, Litonjua AA. Vitamin D and the development of allergic disease: how important is it? Clin Exp Allergy [Internet]. 2015 Jan 1 [cited 2022 Oct 8];45(1):114-25. Doi: https://doi.org/10.1111/cea.12430 PMid:25307157 PMCid:PMC4369152

Berraies A, Hamzaoui K, Hamzaoui A. Link between vitamin D and airway remodeling. J Asthma Allergy [Internet]. 2014 Apr 1 [cited 2022 Oct 8];7(7):23. Doi: https://doi.org/10.2147/JAA.S46944 PMid:24729717 PMCid:PMC3979801

Hall SC, Agrawal DK. Vitamin D and Bronchial Asthma: An overview of the last five years. Clin Ther [Internet]. 2017 May 1 [cited 2022 Oct 8];39(5):917. Doi: https://doi.org/10.1016/j.clinthera.2017.04.002 PMid:28449868 PMCid:PMC5607643

Kerley CP, Elnazir B, Faul J, Cormican L. Vitamin D as an adjunctive therapy in asthma. Part 2: A review of human studies. Pulm Pharmacol Ther [Internet]. 2015 Jun 1 [cited 2022 Oct 8];32:75-92. Doi: https://doi.org/10.1016/j.pupt.2015.02.010 PMid:25749414

Statistics From the National Health Interview Survey | NCCIH [Internet]. [cited 2022 Oct 8]. Available from: https://www.nccih.nih.gov/health/statistics-from-the-national-health-interview-survey

Liu J, Dong YQ, Yin J, Yao J, Shen J, Sheng GJ, et al. Meta-analysis of vitamin D and lung function in patients with asthma. Respir Res [Internet]. 2019 Oct 8 [cited 2022 Oct 11];20(1). Doi: https://doi.org/10.1186/s12931-019-1072-4 PMid:31590675 PMCid:PMC6781357

Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DYM. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med [Internet]. 2010 Apr 1 [cited 2022 Oct 11];181(7):699-704. Doi: https://doi.org/10.1164/rccm.200911-1710OC PMid:20075384 PMCid:PMC2868500

Prevalence and risk factors for bronchial asthma in Indian adults: a multicentre study - PubMed [Internet]. [cited 2022 Oct 11]. Available from: https://pubmed.ncbi.nlm.nih.gov/16482947/

Kshatriya RM, Khara N v, Paliwal R, Patel S. Role of flexible fiber-optic bronchoscopy in the diagnosis of pulmonary dis-eases in rural-based tertiary hospital. International Journal of Medical Science and Public Health Online. 2016;873. Doi: https://doi.org/10.5455/ijmsph.2016.05032016379

Jindal SK, Aggarwal AN, Gupta D, Agarwal R, Kumar R, Kaur T, et al. Indian study on epidemiology of asthma, respiratory symptoms and chronic bronchitis in adults (INSEARCH). Int J Tuberc Lung Dis [Internet]. 2012 Sep 1 [cited 2022 Oct 11];16(9):1270-7. Doi: https://doi.org/10.5588/ijtld.12.0005 PMid:22871327

P G, D M. Prevalence and risk factors for bronchial asthma in adults in Jaipur district of Rajasthan (India). Lung India [Internet]. 2006 Jan 1 [cited 2022 Oct 11];23(2):53-8. Available from: https://doaj.org/article/a5bbc50068f54e5ab1fce7392fce1440

Dhrubprasad MK, Sanyal R, Sarma SD, Mohan U, Sarma GD, Bhattacharyya R. Role of Vitamin D in Bronchial Asthma in Eastern India: A Case Control Study. J Res Med Dent Sci [In-ternet]. 2020 Nov 5 [cited 2022 Oct 11];0(0):318-21. Available from: https://www.jrmds.in/articles/role-of-vitamin-d-in-bronchial-asthma-in-eastern-india-a-case-control-study-59322.html

Ali NS, Nanji K. A Review on the Role of Vitamin D in Asthma. Cureus [Internet]. 2017 May 29 [cited 2022 Oct 11];9(5). Doi: https://doi.org/10.7759/cureus.1288

Rehim AA. Occupational Asthma Severity among Flour Mill Workers and Adherence to Preventive Guidelines. Vol. 10, 1076 Indian Journal of Public Health Research & Develop-ment. 2019. Doi: https://doi.org/10.5958/0976-5506.2019.03002.X

Chowdhury NU, Guntur VP, Newcomb DC, Wechsler ME, Weatherald J, Humbert M, et al. Sex and gender in asthma. European Respiratory Review [Internet]. 2021 Dec 31 [cited 2022 Oct 12];30(162). Doi: https://doi.org/10.1183/16000617.0067-2021 PMid:34789462 PMCid:PMC8783601

Ali NS, Nanji K. A Review on the Role of Vitamin D in Asthma. Cureus [Internet]. 2017 May 30 [cited 2022 Oct 12];9(5). Available from: https://pubmed.ncbi.nlm.nih.gov/28680776/

Agrawal S, Pearce N, Ebrahim S. Prevalence and risk factors for self-reported asthma in an adult Indian population: a cross-sectional survey. Int J Tuberc Lung Dis [Internet]. 2013 Feb 1 [cited 2022 Oct 12];17(2). Doi: https://doi.org/10.5588/ijtld.12.0438 PMid:23317966 PMCid:PMC4284294

Dhrubprasad MK, Sanyal R, Sarma SD, Mohan U, Sarma GD, Bhattacharyya R. Role of Vitamin D in Bronchial Asthma in Eastern India: A Case Control Study. J Res Med Dent Sci [In-ternet]. 2020 Nov 5 [cited 2022 Oct 12];0(0):318-21. Available from: https://www.jrmds.in/articles/role-of-vitamin-d-in-bronchial-asthma-in-eastern-india-a-case-control-study-59322.html

Agarwal R, Dhooria S, Aggarwal AN, Maturu VN, Sehgal IS, Muthu V, et al. Guidelines for diagnosis and management of bronchial asthma: Joint ICS/NCCP (I) recommendations. Lung India [Internet]. 2015 Apr 1 [cited 2022 Oct 12];32(Suppl 1):S3-42. Available from: https://europepmc.org/articles/PMC4405919

Globe G, Martin M, Schatz M, Wiklund I, Lin J, von Maltzahn R, et al. Symptoms and markers of symptom severity in asthma--content validity of the asthma symptom diary. Health Qual Life Outcomes [Internet]. 2015 Dec 12 [cited 2022 Oct 12];13(1). Doi: https://doi.org/10.1186/s12955-015-0217-5 PMid:25879643 PMCid:PMC4336744

(PDF) Prevalence and Risk Factors for Bronchial Asthma in Indian Adults: A Multicentre Study [Internet]. [cited 2022 Oct 12]. Available from: https://www.researchgate.net/publication/7294052_Prevalence_and_Risk_Factors_for_Bronchial_Asthma_in_Indian_Adults_A_Multicentre_Study

Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DYM. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med [Internet]. 2010 Apr 1 [cited 2022 Oct 12];181(7):699-704. Doi: https://doi.org/10.1164/rccm.200911-1710OC PMid:20075384 PMCid:PMC2868500

Sharif A, Haddad Kashani H, Sharif MR. Association of 25-hydroxy vitamin D with asthma and its severity in children: a case-control study. Clin Mol Allergy [Internet]. 2020 May 4 [cited 2022 Oct 12];18(1):7. Doi: https://doi.org/10.1186/s12948-020-00122-9 PMid:32390767 PMCid:PMC7197187

Guru H, Shah S, Rasool R, Qadri Q, Guru FR, Bashir S, et al. Correlation between Asthma Severity and Serum Vitamin D Levels: Experience from a Tertiary Care Centre in North In-dia. Journal of Biomedical Sciences [Internet]. 2018 [cited 2022 Oct 12];7(3):0-0. Available from: https://www.itmedicalteam.pl/articles/correlation-between-asthma-severity-and-serum-vitamin-d-levels-experience-from-a-tertiary-care-centre-in-north-india-106896.html