Outcome of Patients with Sepsis Admitted in Intensive Care Unit of a Tertiary Care Hospital in India


  • Rashmi R Patel Gujarat Medical Education and Research Society Medical College, Gandhinagar
  • Vinayak H Karagatharavm Private practitioner, Surgery, Aurangabad
  • Bhavin Dudhrecha Private practitioner, Surgery, Aurangabad




Sepsis, APACHE II, Intensive Care Unit, Co-morbidity


Introduction: Sepsis has a death rate of ∼25% globally and its clinical treatment presents an important clinical challenge. The rapid progression of sepsis requires correspondingly swift adjustments in therapy, and accurate identification of disease severity is therefore vitally important for predicting prognosis, treatment, preventing complications, reducing complication and mortality. With this background, the present research is aimed to study the relation of serum procalcitonin levels in cases with sepsis, to calculate APACHE II scores and to correlate the levels of serum PCT levels with APACHE II Score with the outcome.

Methodology: This was a prospective observational non interventional cohort study was conducted in the Clinic of Intensive Care unit of a tertiary care hospital and medical college in western India from May 2020 to December 2020.

Results: A total of 75 patients, admitted to the ICU with the diagnosis of sepsis, were included in this prospective observational study. Of them 47 (62.7%) were males and highest cases were aged between 60 to 69 years. Of the total 75 patients, 47 (62.7%) patients were survivors. Age, gender and involvement of system were not associated with mortality while lower APACHE II score and presence of co-morbidities were significantly associated with mortality.

Conclusion: From this study we conclude that the lower APCHE II score and presence of co-morbidity significantly increases the mortality in ICU patients admitted with sepsis.


Linde-Zwirble, WT, Angus, DC. Severe sepsis epidemiology: sampling, selection, and society. Crit Care 2004; 8: 222-226. Doi: https://doi.org/10.1186/cc2917 PMid:15312201 PMCid:PMC522859

Vincent JL, and Moreno R. Clinical review. scoring system in the critical ill, Critical Care. 2010;14:207. Doi: https://doi.org/10.1186/cc8204 PMid:20392287 PMCid:PMC2887099

Rapsang AG and Shyam DC. Scoring systems in intensive care unit A compendium. Ind J Critic Care Med. 2014;18(4):220-8. Doi: https://doi.org/10.4103/0972-5229.130573 PMid:24872651 PMCid:PMC4033855

Desai S, and Lakhani JD. Utility of SOFA and APACHE II Score in Sepsis in Rural Set up MICU. Journal of the Association of physicians of India. 2013;61:608-11.

Knaus, WA, Draper, EA, Wagner, DP. APACHE II: a severity of disease classification system. Crit Care Med 1985; 13: 818-829. Doi: https://doi.org/10.1097/00003246-198510000-00009 PMid:3928249

Jamal Q, Rahman AS, Muhammad A, Siddiqui MA, Riaz M, Ansari M and Saleemullah. Apache II scoring as an index of severity in Organ phosphorus Poisoning. J Clin Toxicol. 2014;7:354.

Bouch CD, and Thompson JP. Severity Scoring System in the critically ill. Continuing Education in Anaesthesia. Critical Care Pain J. 2008;8(5):181-5. Doi: https://doi.org/10.1093/bjaceaccp/mkn033

Johnsons S and Saranya AVR, Comparison of different scoring systems used in intensive care unit. J Pulm Repair Med. 2015;5:276. Doi: https://doi.org/10.4172/2161-105X.1000276

Schmeider, HG, Lam, QT. Procalcitonin for the clinical laboratory: a review. Pathology 2007; 39: 383-390. Doi: https://doi.org/10.1080/00313020701444564 PMid:17676478

Bloos, F, Marshall, JC, Dellinger, RP. Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study. Crit Care 2011; 15: R88-R88. Doi: https://doi.org/10.1186/cc10087 PMid:21385367 PMCid:PMC3219347

ArteroA , Zaragoza R et al. Prognostic factors of mortality in patients with community acquired blood stream infection with severe sepsis and septic shock. Journal of Critical Care; 2010; 25; 2; 276-281. Doi: https://doi.org/10.1016/j.jcrc.2009.12.004 PMid:20149587

Jain S, Sinha S et al. Procalcitonin as a prognostic marker for sepsis: a prospective observational study. BMC Research Notes. 2014; 7:458. Doi: https://doi.org/10.1186/1756-0500-7-458 PMid:25034373 PMCid:PMC4105100

Nargis W, Ibrahim M et al. Procalcitonin versus C-reactive protein: Usefulness as biomarker of sepsis in ICU patient. Int J CritIllnInj Sci 2014;4:195-9. Doi: https://doi.org/10.4103/2229-5151.141356 PMid:25337480 PMCid:PMC4200544

Watanbe Y, Oikawa N et al. Ability of procalcitonin to diag-nose bacterialinfection and bacteria types compared with-blood culture findings. International Journal of General Med-icine. 2016:9; 325-331. Doi: https://doi.org/10.2147/IJGM.S115277 PMid:27757046 PMCid:PMC5053384

Khan AA, Singh R, Singh PK. Diagnostic and prognostic significance of procalcitonin in septicemia. Int J Adv Med 2017;4:630-4. Doi: https://doi.org/10.18203/2349-3933.ijam20171463

Rhee C, Jones T et al. Prevalence, underlying causes and preventability of sepsis- associated mortality in US acute care hospital. JAMA 2019; Doi: https://doi.org/10.1001/jamanetworkopen.2018.7571 PMid:30768188 PMCid:PMC6484603

Arturo Artero, Rafael Zaragoza and José Miguel Nogueira (2012). Epidemiology of Severe Sepsis and Septic Shock, Severe Sepsis and Septic Shock - Understanding a Serious Killer, Dr Ricardo Fernandez (Ed.), ISBN: 978-953-307- 950-9. Doi: https://doi.org/10.5772/27208

Suarez De La Rica et al. Epidemiology of sepsis in western countries AnnTransl Med 2016;4(17):325. Doi: https://doi.org/10.21037/atm.2016.08.59 PMid:27713883 PMCid:PMC5050194

Clec'h C, Ferriere F et al. Diagnostic and prognostic value of procalcitonin in patients with septic shock.Crit Care Med. 2004; 32; 5; 1166-1169. Doi: https://doi.org/10.1097/01.CCM.0000126263.00551.06 PMid:15190968

Anand D, Das S et al. Inter relationship between procalcitonin and organ failure in sepsis..Ind J Clin Biochem. 2014;29:93-96. Doi: https://doi.org/10.1007/s12291-013-0326-z PMid:24478557 PMCid:PMC3903936

Mustafić. S et al. Diagnostic and prognostic value of procalcitonin in patients with sepsis. MedicinskiGlasnik . 2018;15(2): 93-100.

Duplessis C et al. Evaluating the discriminating capacity of cell death (apoptotic) biomarkers in sepsis. Journal of intensive care. 2018; 6; 72; 1-11. Doi: https://doi.org/10.1186/s40560-018-0341-5 PMid:30459950 PMCid:PMC6234551




How to Cite

Patel, R. R. ., Karagatharavm, V. H., & Dudhrecha, B. . (2022). Outcome of Patients with Sepsis Admitted in Intensive Care Unit of a Tertiary Care Hospital in India. National Journal of Medical Research, 12(02), 18–22. https://doi.org/10.55489/njmr.1222022897



Original Research Articles