PREDICTORS OF MORTALITY IN HOSPITALIZED PATIENTS OF ALCOHOLIC LIVER DISEASE

Abstract

Aims and objectives: To correlate mortality with poor prognostic factors like age, clinical features, laboratory investigations, Child Pugh score and MELD score in patients with alcoholic liver disease admitted in tertiary care centre, so as to have suggestions to improve the standards of treatment in alcoholic liver disease.

Materials and methods: This study is a prospective observational study of 50 patients hospitalized in a tertiary care hospital over a period of one year.

Results: The various predictors of mortality in patients with alcoholic liver disease included: higher mean TLC, higher bilirubin, higher transaminases and alkaline phosphatase, higher prothrombin time and INR, low serum sodium, higher serum creatinine, higher grade of hepatic encephalopathy, presence of ascites, larger liver size, portal vein diameter >1.1 cm, presence of large esophageal varices, presence of PHG, requirement of inotrope support and renal replacement therapy. MELD score was a reliable predictor of mortality.

Conclusion: The study highlights various predictors of mortality in case of alcoholic liver disease patients that may help us in early recognition of poor outcome and aggressive management of patients to decrease mortality.