NEONATAL HYPERBILIRUBINEMIA AND ITS CORRELATION WITH G6PD ENZYME DEFICIENCY IN A TERTIARY CARE HOSPITAL IN GUJARAT

NEONATAL HYPERBILIRUBINEMIA AND ITS CORRELATION WITH G6PD ENZYME DEFICIENCY IN A TERTIARY CARE HOSPITAL IN GUJARAT

Authors

  • Aditi Dholakia Gotri Medical College, GMERS
  • Dimple Darad Gotri Medical College, GMERS
  • Savitri Chauhan Gotri Medical College, GMERS

Keywords:

G-6-PD, Hyperbilirubinemia, Prematurity, Methhemoglobin

Abstract

Background: Neonatal Hyperbilirubinemia is one of the commonest abnormal physical findings in the new borns. Although, not a major cause of neonatal mortality, its morbidity during neonatal period makes its early recognition and management important. Amongst the various etiological factors, G-6-PD enzyme deficiency is one of the important causes of neonatal hyperbilirubinemia.

Objective: The purpose of this study is to identify incidence of G-6-PD enzyme deficiency among hyperbilirubinemic neonates & to know about particular caste involved in the studied area.

Methods: In the present study neonates were tested and analysed by a micromethod (based on classical methhemoglobin reduction test) which requires only 20 µl of blood in a minimal laboratory set up as a routine investigation. Influence of various other etiological factors i.e. mode of delivery, birth weight, consangious marriages etc. on neonatal serum bilirubin level were also analysed.

Results: Most of neonates (81.2%) having G-6-PD deficiency were male. Bhanushali (17.85%) and Muslim (11.6%) caste showed higher incidence of G-6-PD deficiency. ABO Incompatibility and Prematurely were associated with 32.6% and 30.6% G-6-PD deficiency neonates respectively.

Conclusion: The present study concludes that higher incidence of Neonatal Hyperbilirubinemia in G-6-P.D deficient neonates due to clustering of casts in some geographical areas of Gujarat.

 

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Published

2012-03-31

How to Cite

Dholakia, A. ., Darad, D. ., & Chauhan, S. . (2012). NEONATAL HYPERBILIRUBINEMIA AND ITS CORRELATION WITH G6PD ENZYME DEFICIENCY IN A TERTIARY CARE HOSPITAL IN GUJARAT. National Journal of Medical Research, 2(01), 59–62. Retrieved from https://njmr.in/index.php/file/article/view/715

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Original Research Articles
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