A COMPARATIVE STUDY OF 2% LIGNOCAINE VS 50% MAGNESIUM SULPHATE FOR ATTENUATION OF STRESS RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Abstract

Introduction: Laryngoscopy and Endotracheal intubation are heart of airway management, but it induces stress response which is very detrimental for the patient. Magnesium sulphate and lignocaine has been tried to reduce the stress response during laryngoscopy and endotracheal intubation.

Method: 42 patients of ASA1 and2 aged 15-65 years of age randomly allocated in 2 groups, 21 patients group A received inj. Magnesium sulphate 50mg/kg added to100ml of normal saline given over half an hour before induction of anesthesia and 3cc NS given 90s before intubation, while Group B received inj. Lignocaine 1.5mg/kg given 90s before intubation after giving 100ml NS over half an hour before induction. All patients were monitored throughout the surgery and observations were made with respective to HR, SBP, DBP, MAP and SPO₂ at various intervals.

Result: Magnesium sulphate provide fairly good and sustained control over haemodynamic response to the stress of laryngoscopy and intubation and is significantly better than lignocaine. The students paired [t] test was used for statistical analysis.

Conclusion: Magnesium sulphate is better alternative to lignocaine for attenuation of stress response of laryngoscopy and intubation.