TRENDS OF ENDOMETRIAL CANCER IN CENTRAL INDIA: AN INSTITUTIONAL REVIEWTrends of Endometrial Cancer in Central India: An Institutional Review

Abstract

AIM: To study the demographics, staging, treatment details, and outcomes of operable endometrial cancers.

METHOD: All operable endometrial cancers treated between January 2013 and February 2017 were included in the study. The details regarding demographics, staging, surgical procedure, pathological staging, adjuvant treatment, and outcomes were extracted from the case records.

RESULTS: There were 25 patients with a median age of 55 years (36–78 years). The Eastern Cooperative Oncology Group performance status was 1 in 23 patients (92%) and 2 in 1 patient (4%) and 3 in 1 patient (4%). 22 patients (88%) had disease restricted to endometrium while 3 patients (12%) had cervical involvement. The surgery done was Type I hysterectomy in 24 patients (96%), Type II in 1 patient (4%). Pelvic lymph node dissection was done in 22(88%) patients while para‑aortic (infra-hilar) dissection was done in 2 patients (8%). The pathological stages were Stage IA in 13 patients, Stage IB in 3 patients, Stage II in 4 patients, Stage IIIC1 in 3 patients, and Stage IV in 2 patients. Grade 1 tumors were seen in 21 patients, Grade 2 in 2 patients, Grade 3 in 2 patients. The histology was endometrioid in 23 patients, clear cell in 1 patient, and carcinosarcoma in 1 patient. Adjuvant treatment was received by 5 patients.

CONCLUSION: Endometrial cancer is 4^th most common gynaecological cancer in our series, 3.5% of all cancer patients. Risk factors including menopause. Other risk factors not statistically significant. Endometrioid adenocarcinoma most common histology with early stage is most common among all surgically treated patients. Simple hysterectomy sufficient for stage 1 & 2. Adjuvant therapy needed in stage 3 & 4. DFS and OS are good in younger age groups, well-differentiated, early stage endometrial cancers but very poor in older age group, poorly differentiated, stage 3C and stage 4 patients.