COMPARISON OF BRONCHODILATORY EFFICACY POTENTIAL OF RACEMIC SALBUTAMOL AND LEVOSALBUTAMOL IN PATIENTS WITH MILD TO MODERATE PERSISTENT ASTHMA

COMPARISON OF BRONCHODILATORY EFFICACY POTENTIAL OF RACEMIC SALBUTAMOL AND LEVOSALBUTAMOL IN PATIENTS WITH MILD TO MODERATE PERSISTENT ASTHMA

Authors

  • Nimit V Khara Pramukhswami Medical College, Karamsad
  • Anand K Patel GMERS Medical College, Gotri
  • Kiran C Rami GMERS Medical College, Patan
  • Firoj D Ghanchi MP Shah Medical College, Jamnagar

Keywords:

Racemic Salbutamol, Levosalbutamol, Bronchodilator, Asthma

Abstract

Introduction: The World Health Organization has estimated that 15 million disability-adjusted life years (DALYs) are lost annually due to asthma, representing 1% of the total global disease burden. Racemic Salbutamol and Levo Salbutamol both have potent broncho-dilatory effect and therefore, both are used in the treatment of Asthma. The study was conducted to compare bronchodilatory efficacy potential of Salbutamol with Levo-Salbutamol.

Methodology: The present study was conducted among 100 patients at a tertiary care hospital mild to moderate persistent asthma. Patients were divided in two groups, 50 subjects in each group. After performing baseline spirometry, group A and group B subjects were given 2.5 mg salbutamol and 1.25 mg levosalbutamol, respectively, through nebulizer (continuous, compressor type of nebulizer with drug particle size 0.5-5 micron and average nebulization rate 0.2ml/min.). After 20 minutes, repeat spirometry was performed to measure bronchodilatory response.

Results: Two groups are comparable for base line characteristics, as there is no age & sex wise and symptom wise significant difference in the distribution of patients (p >0.05 for all variables). Overall picture is suggestive of no significant statistical difference in bronchodilatory potential between Salbutamol and Levo-Salbutamol. Positive raise in FEV1, FEV1/FVC% and PEFR is statistically not significant in both groups (P>0.05 for all three).

Conclusion: Salbutamol and Levo-Salbutamol had isoeffective bronchodilatory potential in bronchial asthma patients when used at equipotent doses.

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Published

2013-09-30

How to Cite

Khara, N. V. ., Patel, A. K. ., Rami, K. C., & Ghanchi, F. D. (2013). COMPARISON OF BRONCHODILATORY EFFICACY POTENTIAL OF RACEMIC SALBUTAMOL AND LEVOSALBUTAMOL IN PATIENTS WITH MILD TO MODERATE PERSISTENT ASTHMA. National Journal of Medical Research, 3(03), 233–235. Retrieved from https://njmr.in/index.php/file/article/view/633

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Original Research Articles

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