CALCIUM DOBESILATE IN SYMPTOMATIC TREATMENT OF HEMORRHOIDAL DISEASE: AN INTERVENTIONAL STUDY
Keywords:Calcium dobesilate, hemorrhoidal disease
Introduction: Hemorrhoidaldisease is one of the commonest ailments that affects mankind and is currently believed to be caused by distal displacement and structural distortion of anal cushions, which are physiologic structuresA randomized, double blind, controlled study was conducted to investigate the efficacy of oral and local calcium dobesilate therapy in treating acute attacks of internal hemorrhoids.
Methods: fiftynine (59)adult patients with first or second-degree internal hemorrhoids were treated with calcium dobesilate for six weeks, while 56 patients received only a high fiber diet to serve as control. Both symptoms and anoscopic inflammation were scored on a scale from 0 to 2 before and six weeks after treatment.
Results: Asuccess rateof 83.05% percent with cessation of bleeding plus lack of severe anitis anoscopically at 6 weeks were achieved with calcium dobesilate. The pretreatment symptoms score of 2 were fell significantly to 0.39±0.16 and the pretreatment anitis score of 1.73±0.12 fell to 0.59±0.17 at 6 weeks (p=0.0002 for both comparisons). The symptoms and anoscopic inflammation score obtained with calcium dobesilate therapy were also significantly better than those with diet only. (P=0.0016 and p=0.0014,respectively).
Conclusions: oral as well as local calcium dobesilate treatment supplemented with diet and bowel habits discipline provides an effective, fast, and safe symptomatic relief from acute symptoms of Hemorrhoidal disease. This symptomatic relief is associated with significant improvement in anoscopically observed inflammation.
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