ROLE OF DURATION OF DIABETES IN THE DEVELOPMENT OF NEPHROPATHY IN TYPE 2 DIABETIC PATIENTS
Keywords:Microproteinuria, nephropathy, Type2 diabetes
Introduction: Diabetes has now become the most common single cause of end stage renal disease and about 40% of diabetic patients develop nephropathy. The present study was conducted to find out the relation between duration of diabetes & development of renal disease.
Methodology: The study was conducted in 120 patients with Type 2 diabetes. Three groups were selected with 40 patients in each group – with diabetes of <5year duration, 5-10year duration and >10year duration. 40 normal healthy adults were included in the control group. Parameters like BP, blood urea, serum creatinine, urine microprotein were compared with controls.
Results: As duration increases, there is impairment of renal function as evidenced by increase in blood urea, serum creatinine & microproteinuria. Statistically significant increase in BP was also observed with increase in duration. Both metabolic & hemodynamic factors play a decisive role in the development of nephropathy. AGEs, PDGF, TGFβ, VEGF, and Angiotensin II etc. stimulate growth & fibrotic factors leading to renal damage.
Conclusion: Screening for microalbuminuria will allow early identification of patients with nephropathy. It has been shown that meticulous glycemic & bloodpressure control can slow the progression of diabetic nephropathy. Developing countries like India with its large burden of diabetes should evolve strategies for prevention of its secondary complications.
How to Cite
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
National Journal of Medical Research © 2011 by Medsci Publication is licensed under Attribution-ShareAlike 4.0 International
Based on work at www.njmr.in.