COMPARISON OF RECOVERY PROFILES OF PROPOFOL & SEVOFLURANE ANESTHESIA WITH BISPECTRAL INDEX MONITORING (BIS) IN GENERAL ANESTHESIA

Abstract

Background: The aim of the study was to compare the effect of propofol & sevoflurane with respect to hemodynamic changes, recovery profiles and complications in patients scheduled for various elective surgical procedures under general anesthesia.

Method: Fifty ASA physical status I-II patients of either sex, aged between 18 and 60 years were randomly divided into two groups to receive either propofol infusion (group P, n=25) or sevoflurane (group S, n=25). Cardiovascular parameters, SpO₂ and bispectral index (BIS) scores were recorded. Time to eye opening, hand squeezing and achieve modified Aldrete’s Score ≥ 9 and the incidence of complications were noted.

Results: Early recovery times [eye opening, hand squeezing and achieve modified Aldrete’s Score ≥ 9] were significantly longer in group P (P  0.001). Cardiovascular parameters, SpO₂ and bispectral index (BIS) scores were comparable between the groups (P > 0.05). The incidence of post-operative nausea and vomiting was significantly higher in group S.

Conclusions: The present study which adjusted propofol infusion rate and sevoflurane concentration according to BIS scores revealed that maintenance of anesthesia with sevoflurane is associated with faster recovery than anesthesia with propofol. Propofol resulted in a significantly lower incidence of postoperative nausea and vomiting.