TENOFOVIR INDUCED SEVERE LACTIC ACIDOSIS AND HEPATITIS

TENOFOVIR INDUCED SEVERE LACTIC ACIDOSIS AND HEPATITIS

Authors

  • Chirag M Chhatwani SMIMER, Surat
  • Jinesh B Purohit SMIMER, Surat
  • Ankit P Vakil SMIMER, Surat
  • Sanjay L Khunt SMIMER, Surat

Keywords:

HIV, Anti retroviral therapy, Tenofovir, Severe Lactic Acidosis, Hepatitis

Abstract

Tenofovir induced hepatitis and severe lactic acidosis is rare. We report a rare case of tenofovir causing hepatitis in severe lactic acidosis in a seropositive patient with none of the identifiable risk factor. A 50 years old seropositive male on ZLN (Zidovudine, Lamivudine, Nevirapine) regimen since 3 years admitted under medicine care with complaints of weakness, fatigability and giddiness since 1 month. All investigations were normal apart from hemoglobin which was 4.5 gm/dL. ART regimen was changed to TLE (Tenofovir, Lamivudine, Efavirenz). After 3 days, patient had nausea, vomiting, upper abdominal pain and breathlessness. Investigations showed aspartate transaminase was 2400 IU/L, alanine transaminase 2706 IU/L, serum bilirubin 0.6 mg/dL, alkaline phosphatase 108 IU/L, PT 14 sec, INR 1.4, serum urea 16 mg/dL and serum creatinine 0.8 mg/dL. Arterial blood gas evaluation showed pH 6.96, PaO 2 116, PaCO2 12, HCO3 1.6. Serum lactate levels were 42 mg/dl. Viral markers were negative. Diagnosis of tenofovir induced hepatitis and lactic acidosis was made. Patient improved after stopping Tenofovir.

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Published

2016-09-30

How to Cite

Chhatwani, C. M., Purohit, J. B. ., Vakil, A. P. ., & Khunt, S. L. . (2016). TENOFOVIR INDUCED SEVERE LACTIC ACIDOSIS AND HEPATITIS. National Journal of Medical Research, 6(03), 288–289. Retrieved from https://njmr.in/index.php/file/article/view/295

Issue

Section

Case Report
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