COMPARISON OF EFFECTS OF MAGNESIUM SULPHATE V/S CLONIDINE AS AN ADJUVANT TO EPIDURAL BUPIVACAINE IN LOWER ABDOMINAL AND LOWER LIMB SURGERIES

Abstract

Introduction: A prospective, randomized, controlled clinical trial was carried out to evaluate the effects of Magnesium sulphate as an adjuvant to epidural bupivacaine and compared with clonidine along with epidural bupivacaine.

Aims and Objective: Main objective to evaluate the efficacy of epidural magnesium sulphate & clonidine used as an adjuvant to bupivacaine.

Material and method: After approval from institutional ethical committee 90 patients undergoing lower abdominal &lower limb surgeries selected and devided in 3 groups Control group, magnesium group and clonidine group and different parameters observed.

Observation: Co-administration of inj. Magnesium sulphate 50 mg. or Clonidine 3µg/kg (150µg maximum) to epidural bupivacaine produced predictable rapid onset of surgical anaesthesia without significant side effects. Addition of clonidine to epidural bupivacaine produced prolonged duration of analgesia with mild sedation compared to magnesium sulphate.

Conclusion: From the study it is suggested that magnesium sulphate can be a useful alternative as an adjuvant to epidural bupivacaine without any side effects.