A STUDY ON CORRELATION OF PATTERN OF FEVER IN COVID 19 POSITIVE PA-TIENTS WITH CORRELATION TO BIOCHEMICAL PARAMETERS

Abstract

Introduction: The novel coronavirus, SARS-CoV-2 presented with a wide array of clinical, inflammatory and radiological manifestations. Currently, a very few data is available about the relationship in between pattern of fever and biochemical parameters in patients affected by COVID-19. Our objective is to find out the clinical and inflammatory status of COVID-19 patients and whether there is a relationship in between pattern of fever and biochemical parameters of severe acute respiratory syndrome coronavirus disease 2.

Methodology: A retrospective study conducted on 60 COVID-19 positive patients, who were clinically/ radiologically evaluated and screened for inflammatory markers.

Result: 39 men and 21 women had Fever and elevated inflammatory markers like CRP, D-dimer, ferritin, ESR. Altered neutrophil lymphocyte ratio was also found. Patients with moderate and severe grade fever had more significant rise in CRP (60%), D-dimer (50%). patients with mild and moderate fever had more rise of ferritin (65%).ESR and NLR were not significantly increased. Patients with intermittent fever had high rise in CRP (80%), D-dimer (75%), and ferritin (72%). Again, ESR was not significantly raised. NLR was moderately raised in patients with continuous fever (66%). Sub acute and chronic rise of temperature shows more significant rise in CRP (60%), D-dimer (82%), ferritin (80%), NLR and ESR.

Conclusion: Our study results shows that fever pattern in COVID-19 infection correlates with the inflammatory biochemical markers. Our study might be of help regarding early diagnosis of severity and timely intervention of COVID-19 infected patients to prevent morbidity and mortality.