EVALUATION OF ACTIVITIES OF SERUM GAMMA GLUTAMYL TRANSFERASE AND ADENOSINE DEAMINASE IN PRE-ECLAMPSIA-A CASE CONTROL STUDY

Abstract

Introduction: Preeclampsia is a Pregnancy Specific Syndrome characterised by Hypertension with BP 140/90 mm Hg or more, Proteinuria and Oedema contributing significantly to Maternal and Foetal Morbidity and Mortality. Endothilial cell dysfunction within the Uteroplacental circulation leads to systemic release of Gamma Glutamyl Transferase(GGT) . The activity of Serum Adenosine Deaminase(ADA) is also increased due to possible role of enhanced Cell Mediated Immunity during Preeclamsia. In the developing Countries with inadequately cared Pregnancy, Preeclampsia on many occasions remains undetected till major complications supervene. So this Study is undertaken at providing some of the Promising Enzyme Markers as GGT and ADA.

Methodology: Present study comprised Fifty Women with Pre-eclampsia as Cases and Fifty age matched normal pregnant Women as Controls. The Parameters were estimated by Standard Biochemical Methods. Statistical Analysis of the Data was done by Student’s t Test and ANOVA.

Results: The activity of Serum GGT was significantly increased in Pre-eclampsia Patients compared to Normal Pregnant Women with a p˂0.001, and there was a highly significant increase in Serum ADA with p<0.000

Conclusion: The Study concludes that Enzyme Markers like Serum GGT and ADA could be Sensitive, Accurate and Cost effective Biomarkers in aiding the Diagnosis and to assess the severity of Preeclampsia.