A COMPARATIVE STUDY EFFICACY OF ONDANSETRON VERSUS GRANISETRON TO PREVENT PERIOPERATIVE NAUSEA AND VOMITING AMONG PATIENTS UNDER GOING GYNAECOLOGICAL SURGERY UNDER SPINAL ANAESTHESIA IN A TERTIARY CARE HOSPITAL OF WESTERN INDIA

Abstract

Background: A randomized double blind study was conducted to compare efficacy of Ondansetron versus Granisetron among patients undergoing gynaecological surgery under the spinal anaesthesia.

Objective: To compare Ondansetron and Granisetron for prevention of postoperative nausea and vomiting in patients undergoing gynaecological surgery under spinal anaesthesia.

Material and methods: Total 60 consecutive patients, age between 18-58 years, ASA grade I and II undergoing gynaecological surgery under the spinal anaesthesia were randomized into two groups of 30 each. One group received I.V. Ondansetron 4.0 mg and the second received I.V. Granisetron 2.0 mg 5 minutes before induction of anaesthesia. For the first 24 hours postoperatively all episodes of nausea and vomiting were recorded. The observations were tabulated and analysed.

Results: In this study found that during early postoperative period (0-3 hrs) there was no statistically significant difference in the study groups. Statistically significant difference was found in the study groups in the late postoperative period (3-24 hrs).

Conclusion: In the early postoperative period both Ondansetron and Granisetron are equally effective in preventing postoperative nausea and vomiting in patients undergoing gynaecological surgery under spinal anaesthesia. Granisetron is better than Ondansetron in the late postoperative period of upto 24 hrs.