EFFECT OF ORAL CLONIDINE AND ORAL GABAPENTINE AS PREMEDICATION ON HEMODYNAMIC STRESS RESPONSES DURING LARYNGOSCOPY AND TRACHEAL INTUBATION AND DURATION OF POST OPERATIVE ANALGESIA

Abstract

Introduction: Direct laryngoscopy and passage of endotracheal tube are noxious stimuli that can provoke stress response in cardiovascular, respiratory and other physiological systems. This study was planned to evaluate the effect of oral Gabapentin and oral clonidine on laryngoscopic stress response and postoperative pain relief.

Methods: 90 patients between the age group 18 to 60 years belonging to ASA class I and II scheduled for lower abdominal surgeries were devided into three groups. Each patient was given 0.2mg inj. Glycopyrolate i.m and oral tab. Clonidine 0.2mg (group C) or oral tab. Gabapentine 900mg (group G) or oral tab. vitamine C (group P) 30 min before surgery.

Results: Oral Clonidine (0.2 mg) when given in premedication provided better attenuation of hemodynamic stress response to laryngoscopy and tracheal intubation compared to oral Gabapentine (900 mg), where hypertensive response was fairly obtunded, but not the tachycardiac response.

Conclusion: Oral Clonidine has better response over tachycardia than Gabapentine, whereas Gabapentine is superior to clonidine for post-operative analgesia.