A Symbiotic Relation Between Anti-Mullerian Hormone (AMH) and Vitamin D in Polycystic Ovary Syndrome (PCOS): A Meta-Analysis and Systematic Review

Kandarp J Patel; Haiya J Sheth; Nidhi Y Mangrola; Neeti A Patel

doi:10.55489/njmr.150420251183

Authors

Kandarp J Patel Department of Pharmacology, Kiran Medical College, Surat, India https://orcid.org/0009-0009-7515-2555
Haiya J Sheth Department of Pharmacology, Kiran Medical College, Surat, India https://orcid.org/0009-0008-5521-5072
Nidhi Y Mangrola Department of Community Medicine, Kiran Medical College, Surat, India https://orcid.org/0000-0003-2958-1972
Neeti A Patel Department of Biochemistry, Parul Institute of Medical Sciences and Research, Parul University, Vadodara, India

DOI:

https://doi.org/10.55489/njmr.150420251183

Keywords:

Anti-Mullerian Hormone, Meta analysis, Ovarian Reserve, Polycystic Ovary Syndrome, Vitamin D

Abstract

Background: The association of vitamin D levels with AMH and other hormones is still under exploration as mentioned in the existing literature. The capacity of vitamin D to regulate ovarian reserve, measured by the AMH level, is a subject of much discussion, especially in PCOS women. Thus, the present study was planned with a primary aim to assess and summarize the available evidence about the interrelationship between vitamin D and AMH levels in PCOS.

Methods: A detailed literature search was done across various databases based on PRISMA guidelines till December 2024. Meta-analysis was done on 10 articles from the 37 articles selected for systematic review.

Results: Serum AMH levels in PCOS subjects significantly decreased (SMD=-0.57; CI: -1.1 to 0.04; p=0.03) on vitamin D supplementation, while, it increased (SMD=-0.67; CI: 0.12 to 1.23; p=0.02) in non-PCOS women.

Conclusion: This indicates a complex interplay of metabolic and hormonal parameters and makes vitamin D a potential factor for PCOS management.

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