Epidemiology of Craniofacial Anomalies: A Retrospective Analysis at a Tertiary Care Teaching Hospital in Southern India

Authors

  • Archi Rai Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India
  • Lahari U Department of Community Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India https://orcid.org/0009-0006-6913-0702
  • Abhipsha Tikayat Ray Department of Oral and Maxillofacial Surgery, Meenakshi Amma Dental College and Hospital, MAHER University, Maduravoyal, Chennai, Tamil Nadu, India
  • Sneha Deepak Mallya Department of Community Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India
  • Adarsh Kudva Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India
  • Saniya Shetty Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India
  • Leslie Edward S Lewis Department of Paediatrics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India

DOI:

https://doi.org/10.55489/njmr.150320251122

Keywords:

Craniofacial Anomalies, Cleft Lip, Cleft Palate, Microcephaly

Abstract

Craniofacial anomalies are congenital malformations that impact essential functions like breathing, feeding, and speech, influenced by genetic and environmental factors. This retrospective study analyzed 54 cases of craniofacial anomalies in neonates at a tertiary care hospital in Karnataka, India, from 2022 to 2023. Data was extracted from electronic medical records and entered and analyzed using the Statistical Package for Social Sciences (SPSS) version 27.0. Most cases were from rural areas (92.6%) and predominantly male (68.5%), with 60.4% being first-born children. The notable percentage of CFAs among male, firstborn children from rural areas underscores the need for enhanced prenatal diagnostics and early intervention in underserved communities. Further research into region-specific genetic and environmental factors may provide valuable insights for reducing the incidence of CFAs.

References

Shaw DW. Global strategies to reduce the health care burden of craniofacial anomalies: report of WHO meetings on international collaborative research on craniofacial anomalies. Cleft Palate Craniofac J. 2004 May;41(3):238-43. DOI: https://doi.org/10.1597/03-214.1 PMid:15151440 DOI: https://doi.org/10.1597/03-214.1

Fitriasari S, Trainor PA. Gene-environment interactions in the pathogenesis of common craniofacial anomalies. Curr Top Dev Biol. 2023;152:139-168. DOI: https://doi.org/10.1016/bs.ctdb.2022.10.005 PMid:36707210 DOI: https://doi.org/10.1016/bs.ctdb.2022.10.005

Dufresne CR. Craniofacial deformities: etiologies, distribution, and classification. Craniomaxillofacial Reconstructive and Corrective Bone Surgery. 2019;23-38. DOI: https://doi.org/10.1007/978-1-4939-1529-3_3 DOI: https://doi.org/10.1007/978-1-4939-1529-3_3

Mossey P, Little J. Addressing the challenges of cleft lip and palate research in India. Indian J Plast Surg. 2009;42(3):9. DOI: https://doi.org/10.4103/0970-0358.57182 PMid:19884687 PMCid:PMC2825065 DOI: https://doi.org/10.4103/0970-0358.57182

Bhide P, Kar A. A national estimate of the birth prevalence of congenital anomalies in India: systematic review and meta-analysis. BMC Pediatr. 2018 May 25;18(1):175. DOI: https://doi.org/10.1186/s12887-018-1149-0 PMid:29801440 PMCid:PMC5970488 DOI: https://doi.org/10.1186/s12887-018-1149-0

Junaid M, Slack-Smith L, Wong K, Bourke J, Baynam G, Calache H, et al. Epidemiology of Rare Craniofacial Anomalies: Retrospective Western Australian Population Data Linkage study. J Pediatr. 2022 Feb;241:162-172.e9. DOI: https://doi.org/10.1016/j.jpeds.2021.09.060 PMid:34626670 DOI: https://doi.org/10.1016/j.jpeds.2021.09.060

Mishra S. Pediatric craniofacial defects: The Indian scenario. 2015;11:Doc161. DOI: https://doi.org/10.3205/cpo001126.

Odhiambo A, Rotich EC, Chindia ML, Macigo FG, Ndavi M, Were F. Craniofacial anomalies amongst births at two hospitals in Nairobi, Kenya. Int J Oral Maxillofac Surg. 2012;41(5):596-603. DOI: https://doi.org/10.1016/j.ijom.2012.01.018 PMid:22521672 DOI: https://doi.org/10.1016/j.ijom.2012.01.009

Aziza A, Kandasamy R, Shazia S. Pattern of craniofacial anomalies seen in a tertiary care hospital in Saudi Arabia. Ann Saudi Med. 2011;31(5):488-493. DOI: https://doi.org/10.4103/0256-4947.84626 PMid:21911986 PMCid:PMC3183683 DOI: https://doi.org/10.4103/0256-4947.84626

Sawasdipanich N, Chaithat B, Rojvachiranonda N, Dangsomboon A. Epidemiological Characteristics of Children With Non-Cleft Lip/Palate Craniofacial Anomalies. J Craniofac Surg. 2022 Mar-Apr 01;33(2):610-614.DOI: https://doi.org/10.1097/SCS.0000000000008136 PMid:35385912 DOI: https://doi.org/10.1097/SCS.0000000000008136

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Published

2025-07-01

How to Cite

Rai, A., U, L., Ray, A. T., Mallya, S. D., Kudva, A., Shetty, S., & Lewis, L. E. S. (2025). Epidemiology of Craniofacial Anomalies: A Retrospective Analysis at a Tertiary Care Teaching Hospital in Southern India. National Journal of Medical Research, 15(03), 224–227. https://doi.org/10.55489/njmr.150320251122

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Section

Short Communication