TY - JOUR AU - Dholakia, Aditi AU - Darad, Dimple AU - Chauhan, Savitri PY - 2012/03/31 Y2 - 2024/03/28 TI - NEONATAL HYPERBILIRUBINEMIA AND ITS CORRELATION WITH G6PD ENZYME DEFICIENCY IN A TERTIARY CARE HOSPITAL IN GUJARAT JF - National Journal of Medical Research JA - Natl J Med Res VL - 2 IS - 01 SE - Original Research Articles DO - UR - https://njmr.in/index.php/file/article/view/715 SP - 59-62 AB - <p><strong>Background:</strong> Neonatal Hyperbilirubinemia is one of the commonest abnormal physical findings in the new borns. Although, not a major cause of neonatal mortality, its morbidity during neonatal period makes its early recognition and management important. Amongst the various etiological factors, G-6-PD enzyme deficiency is one of the important causes of neonatal hyperbilirubinemia.</p><p><strong>Objective:</strong> The purpose of this study is to identify incidence of G-6-PD enzyme deficiency among hyperbilirubinemic neonates &amp; to know about particular caste involved in the studied area.</p><p><strong>Methods:</strong> In the present study neonates were tested and analysed by a micromethod (based on classical methhemoglobin reduction test) which requires only 20 µl of blood in a minimal laboratory set up as a routine investigation. Influence of various other etiological factors i.e. mode of delivery, birth weight, consangious marriages etc. on neonatal serum bilirubin level were also analysed.</p><p><strong>Results: </strong>Most of neonates (81.2%) having G-6-PD deficiency were male. Bhanushali (17.85%) and Muslim (11.6%) caste showed higher incidence of G-6-PD deficiency. ABO Incompatibility and Prematurely were associated with 32.6% and 30.6% G-6-PD deficiency neonates respectively.</p><p><strong>Conclusion:</strong> The present study concludes that higher incidence of Neonatal Hyperbilirubinemia in G-6-P.D deficient neonates due to clustering of casts in some geographical areas of Gujarat.</p><p><strong>&nbsp;</strong></p> ER -