CORRELATION OF HORMONAL RECEPTOR AND Her-2/neu EXPRESSION IN BREAST CANCER: A STUDY AT TERTIARY CARE HOSPITAL IN SOUTH GUJARAT

Abstract

Introduction: Breast cancer is the most common cancer in women and leading cause of cancer death in women. In India its incidence is rapidly rising. Present study was aimed to study pattern of expression of Hormone receptor and Her-2/neu in invasive breast carcinoma and to correlate ER PR status and Her-2/neu expression with various Clinicopathological aspects.

Method: The present study was carried out in the Department of Pathology, Government Medical Collage, Surat, from the period of January 2011 to December 2011. Routine H&E staining for histological diagnosis and IHC analysis for ER, PR and Her-2/neu was carried out in all cases.

Result: This study includes total 58 cases of breast malignancies. 94.82% cases of invasive duct carcinoma. The age of patients ranged from 35 to 73 years of age. Majority of tumors are grade 2 (43.10%) followed by grade 3 (29.31%). ER, PR and Her-2/neu expression was seen in 48.27%, 37.93% and 27.58% respectively. Triple negative cases comprised of 25.86% in our study. Significant correlation was observed between hormonal receptor status and Her-2/neu expression.

Conclusion: Our study of ER, PR and Her-2/neu in breast carcinoma by IHC method indicates higher rates of positive expression correlated with various clinicopathological aspects. Higher number of grade 1 tumor showed ER, PR positivity as compared to grade 3 tumors. Inverse relationship was observed between Her-2/neu expression and ER, PR receptor status. Her-2/neu expression was increased with size and high grade of tumor. Her-2/neu expression did not show any significant correlation with age.