Abstract

All Issues >> 2019 >> Issue-4

Abstract

title:A Comparative Study between Mifepristone Vs. Placebo as an Uterine Sensitizer for Second Trimester Abortions

Author:Meetali Parashar, Kiran Trivedi, Sashi Bala Singh, Rajesh Kumar

Keywords:second trimester abortion, mifepristone, misoprostol, induction delivery interval

Type:Original Article

Abstract:"Introduction: Mifepristone can be used prior to prostaglandins as an uterine sensitizer in secondtrimester abortion. This accelerates the expulsion of fetus. This study was done to compare the efficacy and side effects of using oral mifepristone tablet vs placebo 24 hours prior to induction of second trimesterabortion. Methods: This was a randomized control study conducted in the dept of obsand gynae, RIMS. Women for termination of pregnancy between 13 to 20 weeks were selected according to MTP Act. Group A: Women in this group (n=50) received 200mg of oral Tablet Mifepristone 24 hours prior to induction of abortion. Group B: Women in this group (n=50) received tablets of placebo 24 hours prior to induction of abortion. Induction was done in both groups by intracervical application of dinoprostone (PGE2) gel followed by vaginal misoprostol. Data was compared using chi square test. Result::In group A, 36 patients and in group B, only 3 patients expelled within 12-24 hours. whereas 47 patients in group B took more than 24 hours to complete the expulsion process ( p value is <0.00001). In group A, 30 patients had vaginal bleeding upto 100 ml during the entire process of MTP whereas 38 patients had bleeding >200 ml in group B ( p value is < 0.00001).In group A, 42 patients had complete abortion, whereas in group B, only 24patients had expelled completely. Conclusion: Pretreatment with mifepristone in second trimester abortionis an effective uterine sensitizer with safety and good tolerability. "

RSS Feed | About us | Manuscripts | Current Issue | All Issues | Open Archives | Home