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title:Propofol or Sevoflurane – Which is Better with respect to Nausea, Vomiting and Pain Postoperatively?

Author:Purvi Mehta, Shishir Mehta, Deepak Mistry

Keywords:Post operative Nausea & Vomiting, Post operative pain, Laparoscopic surgery

Type:Original Article

Abstract:Introduction: Anesthetic agents today have been designed and marketed to meet specific niche criteria for ambulatory anesthesia. Propofol, Sevoflurane, etc. have significantly increased the ability of the anesthesiologist to provide a successful ambulatory surgical experience for the patient. This study was aimed at assessing the effect of Propofol and Sevoflurane in preventing postoperative nausea, vomiting and pain after laproscopic surgery among the patients of ASA 1 and 2. Methodology: All patients having ASA 1 and ASA 2 physical status scheduled for laparoscopic surgery in the age group 20 to 70 years not having clinically significant cardiovascular, respiratory, hepatic, renal, neurologic, psychiatric or metabolic disease; non-pregnant; not having morbid obesity; not having history of alcohol and drug abuse and willing to give informed consent were included in the study. Patients were randomly divided into two groups, of which one were administered Propofol and two were administered Sevoflurane to maintain anesthesia. Results: There were total 60 patients scheduled for laparoscopic surgery. Out of these 60 patients, 30 were administered Propofol and 30 were administered Sevoflurane as maintenance drug. Maximum number of nausea and vomiting were with Sevoflurane. Total 13 (43.3%) patients were having 4 times Nausea/Vomiting in first four hours postoperatively. Among patients to whom Propofol was administered, 17 (56.7%) not experienced any spell of nausea/vomiting in first 4 hours. Remaining patients also experienced only one spell of nausea/vomiting. post operative mild pain is seen in both group of patient. But moderate to severe pain is seen in Sevoflurane group. Least pain is seen in Propofol group. This suggestive that analgesic property of Propofol is greater than Sevoflurane.

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