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title:Role of Random Urinary Protein to Creatinine Ratio in Mild Preeclampsia

Author:Manoj C Lokhande, Avinash N Jadhao

Keywords:Preeclampsia, Proteinuria, Protein to creatinine (P/C) ratio

Type:Original Article

Abstract:Introduction: Preeclampsia is one of the important members of deadly triad, along with hemorrhage and infection which contributes for the maternal morbidity and mortality rates. Proteinuria is an important diagnostic component of preeclampsia. Aim: To compared the results of s random urine protein-creatinine (P/C) ratio with 24-hour urine protein excretion in women with mild preeclampsia. Methodology: 100 pregnant women with mild preeclampsia as cases and age matched 100 normal healthy pregnant women as controls were studied for proteinuria. Urine P/C ratio was determined in a random sample, and the amount of protein excretion was measured in 24-hour urine collected on the subsequent day and compared between cases and age matched controls of age group 18-35 years using unpaired two-tailed Student ‘t’ test. The correlation between the spot P/C ratio and 24-hour urine protein excretion was assessed. The receiver operating characteristic curve analysis was used to determine the best discriminator values of the spot urine P/C ratios for preeclampsia (proteinuria ? 300 mg/24 h). All statistical analyses were performed using GRAPH PAD PRISM version 5.00 software. Results: There was a strong correlation between the spot P/C ratio and 24-hour urine protein excretion (r = 0.94; P < .0001). ROC curve reveals area 0.95. The optimal spot P/C ratio cutoff point was 0.3 for 300 mg/24 h of protein excretion (preeclampsia), with a sensitivity, specificity, positive predictive value, and negative predictive value of 94%, 94%, 94.4%, and 96.8%, respectively. Conclusion: We found that there is a significant correlation between the spot urine P/C ratio and 24-hour urine protein excretion in women with preeclampsia. Urine P/C ratio could be used for diagnosis as well as screening of mild preeclampsia.

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