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title:A Profile of Cases of Hemoglobinopathies at a Medical College

Author:Shah Sejal J, Chauhan Sanjay C, Rathod Hitesh K, Patel Amul B, Sharma Vaibhavi Y

Keywords:hemoglobinopathies, Beta Thalassemia Major, sickle cell disease

Type:Original Article

Abstract:Background: Present study was carried out with objectives of creating a profile for cases of hemoglobinopathies coming at NHL medical college and comparing the results obtained in present study with those of various studies done in India and abroad. Materials and methods: The study was carried out at the Department of Pathology, N.H.L. Municipal Medical College, Ahmedabad. A total of 35 cases of thalassemias and other hemoglobinopathies were studied. The criteria for case selection were hemoglobin level less than 10 gm%, presence of hepatosplenomegaly, icterus and clinical presumption of hemolytic anemia in general. Details of the cases were recorded in a proforma. Data were then analysed using microsoft excel software. Results: Out of total 35 cases Beta0 Thalassemia Major was the most frequent (40%) followed by homozygous sickle cell disease (20%). More than one third cases (34.3%) were of 10 or more years of age while 31.4% cases were in 1-3 years of age group. Sex wise distribution showed male preponderance (74.3%). Religion wise majority were hindus (80%). Caste wise majority were of general category (83%). Pallor was found in all cases. Most of the cases showed hypochromia, microcytosis, Anisopoikilocytosis, polychromatophilia.

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