Abstract

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Abstract

title:Deficiency of Protein S and Factor V Presenting As Ischemic Stroke in A 14 Years Old Boy

Author:Subhashish Deb, Agnibha Dutta, Ashish Dudhe, Somnath Dasgupta, Amit Sarkar

Keywords:Ischemic Stroke,Stroke in young , Thrombophilia

Type:Case report

Abstract:A 14 year old nondiabetic, nonhypertensive boy was admittedwith left sided hemiparesis. He has been diagnosed with ischemic stroke due to combined deficiency of protein S and factor V.Inherited thrombophiliadue to deficiencies of natural anticoagulants (antithrombin, protein C and protein S) and activated protein C resistance (APC-R) are more commonly associated with venous rather than arterial thrombosis. While deficiency of factor V leads to heamorrhage, some mutations like factor V Leiden predispose for thrombosis .Combined deficiency of both protein C and factor V leading to arterial thrombo-embolism causing ischemic stroke is a rarer event.

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