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title:Small Cell Carcinoma of the Ovary of Hypercalcemic Type: A Rare Tumor

Author:Varun Goel, Chandragouda Dgouda, Sajjan Singh, Shubhra Raina, Vineet Talwar, Nivedita Patnaik, Sunil Pasricha

Keywords:Small Cell Carcinoma, Ovary, Hypercalcemic Type, Immunohistochemistry, chemotherapy

Type:Case report

Abstract:Small Cell Carcinoma of the Ovary of Hypercalcemic Type (SCCOHT) is a rare entity. Very few cases have been reported to date. Most literature about SCCOHT is isolated clinico-pathological series and case reports. We report a case of SCCOHT in a 40 year old female with a pre-operative diagnosis of bilateral ovarian complex cysts. The patient underwent left ovarian cystectomy with right ovarian biopsy and histopathological examination revealed features of a poorly differentiated carcinoma with intervening extensive areas of necrosis (upto 80%). Tumor cells were positive for EMA, CK, CK7 (focally) CD10, synaptophysin and vimentin hence confirming the diagnosis of SCCOHT. Post surgery patient was started on Etoposide and cisplatin based adjuvant chemotherapy. In view of highly aggressive nature of this tumor, prompt diagnosis and imparting effective chemotherapy regimen to the patient is required.

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